Premium
Organocatalytic Enamide–Azide Cycloaddition Reactions: Regiospecific Synthesis of 1,4,5‐Trisubstituted‐1,2,3‐Triazoles
Author(s) -
Danence Lee Jin Tu,
Gao Yaojun,
Li Maoguo,
Huang Yuan,
Wang Jian
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002775
Subject(s) - cycloaddition , azide , chemistry , combinatorial chemistry , click chemistry , organic chemistry , catalysis
Heterocycles in one click : A novel organocatalytic enamide–azide cycloaddition reaction has been developed. This synthetic procedure represents a new method for the efficient construction of 1,4,5‐trisubstituted‐1,2,3‐triazoles under mild reaction conditions. Most significantly, the investigated process is highly regiospecific (see scheme).