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Microwave‐Promoted Selective Mono‐N‐Alkylation of Anilines with Tertiary Amines by Heterogeneous Catalysis
Author(s) -
Lubinu M. Caterina,
De Luca Lidia,
Giacomelli Giampaolo,
Porcheddu Andrea
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002704
Subject(s) - transamination , catalysis , alkylation , transfer hydrogenation , combinatorial chemistry , chemistry , organic chemistry , palladium , computer science , ruthenium , enzyme
A palladium‐catalyzed N‐alkylation of anilines with tertiary amines that occurs under heterogeneous transfer‐hydrogenation conditions has been developed (see scheme). This protocol of transamination, which uses a relatively cheap and easily recyclable heterogeneous catalyst, can be efficiently applied to different substrates and is suitable for large‐scale preparations.