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Modulation of DNA‐Modified Gold‐Nanoparticle Stability in Salt with Concatemeric Single‐Stranded DNAs for Colorimetric Bioassay Development
Author(s) -
Ali M. Monsur,
Kanda Pushpinder,
Aguirre Sergio D.,
Li Yingfu
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002677
Subject(s) - colloidal gold , dna , nanotechnology , nanoparticle , biology , biophysics , chemistry , computational biology , materials science , genetics
Golden island : Periodically assembled gold nanoparticles (AuNPs) on a long single‐stranded DNA (ssDNA) with a repetitive sequence, produced by rolling circle amplification (RCA), form island‐like, globular structures under salted conditions (see figure; green = short DNA probe, orange=AuNP, black=long ssDNA from RCA). The AuNPs in such islands retain their original red color whereas unassembled AuNPs form purple aggregates under the same conditions.