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Surface Modification of Polymeric Micelles by Strain‐Promoted Alkyne–Azide Cycloadditions
Author(s) -
Guo Jun,
Chen Guojun,
Ning Xinghai,
Wolfert Margreet A.,
Li Xiuru,
Xu Bingqian,
Boons GeertJan
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002532
Subject(s) - azide , alkyne , surface modification , micelle , reagent , chemistry , combinatorial chemistry , strain (injury) , click chemistry , polymer chemistry , organic chemistry , catalysis , aqueous solution , medicine
Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain‐promoted alkyne–azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release.