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Well‐Defined Air‐Stable Palladium HASPO Complexes for Efficient Kumada–Corriu Cross‐Couplings of (Hetero)Aryl or Alkenyl Tosylates
Author(s) -
Ackermann Lutz,
Kapdi Anant R.,
Fenner Sabine,
Kornhaaß Christoph,
Schulzke Carola
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002386
Subject(s) - aryl , palladium , catalysis , heteroatom , phosphine , chemistry , combinatorial chemistry , phosphine oxide , coupling reaction , organic chemistry , polymer chemistry , medicinal chemistry , ring (chemistry) , alkyl
Palladium complexes of representative h etero a tom‐substituted s econdary p hosphine o xide (HASPO) preligands were synthesized and fully characterized, including X‐ray crystal structure analysis. Importantly, these well‐defined complexes served as highly efficient catalysts for Kumada–Corriu cross‐coupling reactions of aryl, alkenyl, and even heteroaryl tosylates. Particularly, an air‐stable catalyst derived from inexpensive PinP(O)H displayed a remarkably high catalytic efficacy, which resulted in cross‐couplings at low catalyst loadings under exceedingly mild reaction conditions with ample scope.