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Interaction of the Human Prion Protein PrP106–126 with Metal Complexes: Potential Therapeutic Agents Against Prion Disease
Author(s) -
Wang Yanli,
Xu Jia,
Wang Lu,
Zhang Bingbing,
Du Weihong
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002207
Subject(s) - prion protein , computational biology , human disease , disease , virology , chemistry , biology , medicine , pathology
Fighting the prions! The interaction of Pt‐ and Au‐based metal complexes with the human prion protein fragment PrP106–126 (see figure) was investigated to identify potential therapeutic agents against the prion disease. These findings provide a new therapeutic direction in the design and development of metallodrugs against neurodegenerative diseases.