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The Development of a General Strategy for the Synthesis of Tyramine‐Based Natural Products by Using Continuous Flow Techniques
Author(s) -
Achanta Srinivas,
Liautard Virginie,
Paugh Robert,
Organ Michael G.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002102
Subject(s) - protocol (science) , computer science , tyramine , process (computing) , scale (ratio) , biochemical engineering , chemistry , combinatorial chemistry , process engineering , information retrieval , programming language , engineering , biochemistry , physics , medicine , alternative medicine , pathology , quantum mechanics
A flowing future! A multistep, general flow chemistry protocol has been developed for the preparation of tyramine‐based natural products. The process integrates room‐temperature reactions with high‐temperature Heck coupling reactions, where the heat has been supplied by microwave irradiation. As a proof of concept for ‘scaling out’ to attain larger quantities of the desired products, the four primary tyramine‐based natural products were prepared on a gram scale using this synthetic protocol.