Novel and Efficient Copper‐Catalysed Synthesis of Nitrogen‐Linked Medium‐Ring Biaryls

Herein, a new copper‐catalysed strategy for the synthesis of rare nitrogen‐linked seven‐, eight‐ and nine‐membered biaryl ring systems is described. It is proposed that the reaction proceeds through a highly activated intramolecularly co‐ordinated copper catalyst. The process is technically simple, proceeds under relatively mild conditions, displays a broad substrate scope and forms biologically valuable products that are difficult to synthesise by other methods. We envisage that this methodology will prove useful in a wide synthetic context, with possible applications in both target‐oriented and diversity‐oriented synthesis.