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Novel and Efficient Copper‐Catalysed Synthesis of Nitrogen‐Linked Medium‐Ring Biaryls
Author(s) -
Kenwright Jayne L.,
Galloway Warren R. J. D.,
Blackwell David T.,
IsidroLlobet Albert,
Hodgkinson James,
Wortmann Lars,
Bowden Steven D.,
Welch Martin,
Spring David R.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002093
Subject(s) - copper , ring (chemistry) , nitrogen , chemistry , combinatorial chemistry , catalysis , polymer chemistry , stereochemistry , organic chemistry
Herein, a new copper‐catalysed strategy for the synthesis of rare nitrogen‐linked seven‐, eight‐ and nine‐membered biaryl ring systems is described. It is proposed that the reaction proceeds through a highly activated intramolecularly co‐ordinated copper catalyst. The process is technically simple, proceeds under relatively mild conditions, displays a broad substrate scope and forms biologically valuable products that are difficult to synthesise by other methods. We envisage that this methodology will prove useful in a wide synthetic context, with possible applications in both target‐oriented and diversity‐oriented synthesis.