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Efficient Multicomponent Reaction Synthesis of the Schistosomiasis Drug Praziquantel
Author(s) -
Cao Haiping,
Liu Haixia,
Dömling Alexander
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002046
Subject(s) - praziquantel , schistosomiasis , scalability , computer science , information retrieval , key (lock) , combinatorial chemistry , chemistry , medicine , database , immunology , computer security , helminths
Shorter than ever : A convergent, efficient, and scalable access based on a key Ugi four‐component reaction (4CR) followed by a Pictet–Spengler reaction comprises the shortest known synthesis to the schistosomiasis drug praziquantel (see scheme).