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Kinetic Investigation of a Ligand‐Accelerated Sub‐mol % Copper‐Catalyzed CN Cross‐Coupling Reaction
Author(s) -
Larsson PerFredrik,
Bolm Carsten,
Norrby PerOla
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002021
Subject(s) - copper , ligand (biochemistry) , catalysis , coupling reaction , kinetic energy , chemistry , coupling (piping) , reaction rate , order of reaction , kinetics , materials science , reaction rate constant , physics , organic chemistry , metallurgy , biochemistry , receptor , quantum mechanics
Unique ligand acceleration : A kinetic investigation of the copper‐catalyzed CN cross‐coupling in the sub‐mol % range reveals an exceptional ligand dependence. Dimethylethylenediamine (DMEDA) is unique in promoting this reaction, and even at a ratio of >2000:1 relative to the catalyst, the reaction order is still positive in DMEDA. This discovery allowed the development of milder reaction conditions. The reaction order in copper becomes zero at very low concentration.