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Hybrid‐Increased Radical‐Scavenging Activity of Resveratrol Derivatives by Incorporating a Chroman Moiety of Vitamin E
Author(s) -
Yang Jie,
Liu GuoYun,
Lu DongLiang,
Dai Fang,
Qian YiPing,
Jin XiaoLing,
Zhou Bo
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201002020
Subject(s) - moiety , chemistry , resveratrol , scavenging , redox , electron transfer , molecule , vitamin , vitamin e , photochemistry , stereochemistry , organic chemistry , antioxidant , biochemistry
A winning combination : Resveratrol derivatives incorporating a chroman moiety of vitamin E were constructed, resulting in the remarkable enhancement in tris(2,4,6‐trichloro‐3,5‐dinitrophenyl)methyl radical (HNTTM . )‐scavenging activity as compared with the parent molecules (see scheme). Reaction kinetic analysis, oxidative product identification, and redox potential determination demonstrate that the reaction is governed by a sequential proton‐loss electron‐transfer (SPLET) mechanism.