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C‐2 Arylation of Piperidines through Directed Transition‐Metal‐Catalyzed sp 3 CH Activation
Author(s) -
Prokopcová Hana,
Bergman Sheba D.,
Aelvoet Karel,
Smout Veerle,
Herrebout Wouter,
Van der Veken Benjamin,
Meerpoel Lieven,
Maes Bert U. W.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001887
Subject(s) - catalysis , hydrogen , chemistry , transition metal , metal , vial , hydrogen atom , combinatorial chemistry , atom (system on chip) , photochemistry , organic chemistry , alkyl , computer science , embedded system
All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp 3 )H‐activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition‐metal‐catalyzed functionalizations are still rare. Open‐vial reactions proved crucial to this direct arylation procedure as, upon sealing, catalyst deactivation occurs.