Premium
Dramatic Impact of ppb Levels of Palladium on the “Copper‐Catalyzed” Sonogashira Coupling
Author(s) -
Gonda Zsombor,
Tolnai Gergely L.,
Novák Zoltán
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001880
Subject(s) - sonogashira coupling , palladium , copper , catalysis , aryl , chemistry , coupling (piping) , organic chemistry , materials science , metallurgy , alkyl
Palladacadabra! The effect of ppb levels of palladium on the “copper‐catalyzed” Sonogashira coupling is reported. The observed high sensitivity to palladium impurities queries the existence of pure copper catalysis in the coupling of aryl iodides and terminal acetylenes (see figure).