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A General and Convenient Palladium‐Catalyzed Carbonylative Sonogashira Coupling of Aryl Bromides
Author(s) -
Wu XiaoFeng,
Neumann Helfried,
Beller Matthias
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001864
Subject(s) - sonogashira coupling , aryl , palladium , combinatorial chemistry , carbonylation , computer science , scheme (mathematics) , catalysis , function (biology) , chemistry , organic chemistry , mathematics , carbon monoxide , biology , mathematical analysis , alkyl , evolutionary biology
Convenient carbonylations : An efficient methodology for the carbonylative Sonogashira reaction of aryl bromides has been developed (see scheme). Contrary to known procedures, inexpensive aryl bromides can be applied as substrates to give the desired compounds in moderate to good yields (47–88 %).