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Total Synthesis and Antibiotic Activity of Dehydrohomoplatencin
Author(s) -
Waalboer Dennis C. J.,
Leenders Stefan H. A. M.,
SchülinCasonato Tanja,
van Delft Floris L.,
Rutjes Floris P. J. T.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001744
Subject(s) - antibiotics , ketolide , antibacterial activity , bacteria , derivative (finance) , total synthesis , microbiology and biotechnology , antibacterial agent , stereochemistry , chemistry , biology , combinatorial chemistry , genetics , business , finance
Expanding antibiotics : A concise synthesis of dehydrohomoplatencin, a novel derivative of the naturally occurring antibiotic platencin, has been realized (see scheme). Notably, the synthesis of the ketolide portion of the molecule was achieved in only two exceedingly simple steps. Compared to platencin, dehydrohomoplatencin showed virtually equipotent antibacterial activity against Gram‐positive bacteria and may serve as a novel lead structure for the development of new antibiotics.