One‐Pot Tandem Catalysis: A Concise Route to Fused Bicyclic Scaffolds from Acyclic β‐Ketoesters and Alkynyl Aldehydes | Zendy

Liu Lu | Zendy; Wei Lai | Zendy; Lu Yong | Zendy; Zhang Junliang | Zendy

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One‐Pot Tandem Catalysis: A Concise Route to Fused Bicyclic Scaffolds from Acyclic β‐Ketoesters and Alkynyl Aldehydes

Author(s) -

Liu Lu,

Wei Lai,

Lu Yong,

Zhang Junliang

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201001729

Subject(s) - knoevenagel condensation , tandem , catalysis , combinatorial chemistry , chemistry , organic chemistry , simple (philosophy) , materials science , composite material , philosophy , epistemology

“Quick‐step” synthesis : A rapid and highly efficient route to fused polycyclic scaffolds from simple, readily available β‐ketoesters and alkynyl aldehydes was developed (see scheme) as a one‐pot reaction by combining three fundamental reactions, that is, the Knoevenagel condensation, Nazarov cyclization, and Conia‐ene reactions. Piperidinium acetate was found to be a tandem catalyst in these one‐pot reactions.

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