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One‐Pot Tandem Catalysis: A Concise Route to Fused Bicyclic Scaffolds from Acyclic β‐Ketoesters and Alkynyl Aldehydes
Author(s) -
Liu Lu,
Wei Lai,
Lu Yong,
Zhang Junliang
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001729
Subject(s) - knoevenagel condensation , tandem , catalysis , combinatorial chemistry , chemistry , organic chemistry , simple (philosophy) , materials science , composite material , philosophy , epistemology
“Quick‐step” synthesis : A rapid and highly efficient route to fused polycyclic scaffolds from simple, readily available β‐ketoesters and alkynyl aldehydes was developed (see scheme) as a one‐pot reaction by combining three fundamental reactions, that is, the Knoevenagel condensation, Nazarov cyclization, and Conia‐ene reactions. Piperidinium acetate was found to be a tandem catalyst in these one‐pot reactions.