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Scaling Out by Microwave‐Assisted, Continuous Flow Organic Synthesis (MACOS): Multi‐Gram Synthesis of Bromo‐ and Fluoro‐benzofused Sultams Benzthiaoxazepine‐1,1‐dioxides
Author(s) -
Ullah Farman,
Samarakoon Thiwanka,
Rolfe Alan,
Kurtz Ryan D.,
Hanson Paul R.,
Organ Michael G.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001651
Subject(s) - microwave irradiation , microwave , computer science , gram , scale (ratio) , scaling , flow (mathematics) , continuous flow , flow chemistry , process (computing) , scheme (mathematics) , organic synthesis , chemistry , combinatorial chemistry , information retrieval , process engineering , programming language , physics , biochemical engineering , organic chemistry , biology , telecommunications , engineering , catalysis , mathematics , quantum mechanics , bacteria , mathematical analysis , mechanics , genetics , geometry
Go with the flow! Using a combination of continuous‐flow techniques and microwave irradiation, a 19‐member collection of 5–10 gram quantities of benzthiaoxazepine‐1,1‐dioxides has been produced (see scheme). The elimination of intermediate‐ and large‐scale process optimization by invoking the concept of scale‐out (rather than scale up) has significantly reduced the time necessary to prepare these compounds.