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Insulator Base Pairs for Lighting‐up Perylenediimide in a DNA Duplex
Author(s) -
Kashida Hiromu,
Sekiguchi Koji,
Asanuma Hiroyuki
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001638
Subject(s) - nucleobase , base pair , insulator (electricity) , quantum yield , duplex (building) , quantum , fluorescence , cyclohexane , dna , chemistry , computer science , nanotechnology , optoelectronics , physics , materials science , biochemistry , quantum mechanics , organic chemistry
Quenched : Perylenediimide (PDI) is highly quenched by nucleobases, which greatly restricts its application as a fluorescent probe. Here, we propose “insulator base pairs” tethering cyclohexane ring through D ‐threoninol. When “insulator base pairs” were inserted between PDI and nucleobases, the quantum yield of PDI drastically increased several thousand‐fold. The “insulator base pairs” reported here also have the potential to increase the quantum yields of other fluorophores.