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Isovitamin B 12 : A Vitamin B 12 Derivative That Flips Its Tail
Author(s) -
Murtaza Shahzad,
Ruetz Markus,
Gruber Karl,
Kräutler Bernhard
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001616
Subject(s) - vitamin b12 , derivative (finance) , chemistry , mathematics , economics , biochemistry , financial economics
Base on : Vitamin B 12 is well known as a compact and cobalt‐coordinated base‐on corrinoid, in which the corrin and nucleotide moieties are connected by their natural linker, ( R )‐isopropanolamine. In the synthetic isomer, isovitamin B 12 , an n ‐propanolamine linker produces a structural mismatch. X‐ray crystallography revealed two distinct base‐on conformers of isovitamin B 12 (magenta; inward conformer, yellow: outward conformer).