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Weapons in Disguise—Activating Mechanisms and Protecting Group Chemistry in Nature
Author(s) -
Kwan Jason C.,
Luesch Hendrik
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001562
Subject(s) - natural product , group (periodic table) , chemistry , natural (archaeology) , action (physics) , combinatorial chemistry , nanotechnology , stereochemistry , organic chemistry , materials science , history , physics , quantum mechanics , archaeology
Bioactive natural products often possess uniquely functionalized structures with unusual modes of action; however, the natural product itself is not always the active species. We discuss molecules that draw on protecting group chemistry or else require activation to unmask reactive centers, illustrating that nature is not only a source of complex structures but also a guide for elegant chemical transformations which provides ingenious chemical solutions for drug delivery.