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Enantioselective Organocatalytic Synthesis of Fluorinated Molecules
Author(s) -
Valero Guillem,
Companyó Xavier,
Rios Ramon
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001546
Subject(s) - enantioselective synthesis , synthon , trifluoromethylation , organocatalysis , fluorine , chemistry , catalysis , reagent , molecule , organic chemistry , combinatorial chemistry , optically active , trifluoromethyl , alkyl
Abstract The enantioselective synthesis of fluorinated molecules has drawn much attention within the chemical community due to its unique stereoelectronic properties. The main aim of this review is to cover the most important organocatalytic enantioselective methodologies to obtain them. The review is divided into three parts: first, the direct introduction of a fluorine atom studied in the early 2000s. Second, the later use of Michael reactions to introduce fluorine‐containing synthons. Finally, the simultaneously‐developed trifluoromethylation reactions, giving the catalysts, mechanisms and reagents that have been used.