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Rhodium Mediated CH Bond Functionalisation Leading to Carboxylate Derivatives
Author(s) -
Tejel Cristina,
del Río M. Pilar,
López José A.,
Ciriano Miguel A.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001453
Subject(s) - rhodium , chemistry , carbon monoxide , alkyl , carboxylate , combinatorial chemistry , organic chemistry , catalysis
Selective functionalisation of 1,5‐cyclooctadiene, either to a carboxylic acid or to a γ‐lactone, is achieved by a novel sequence of reactions involving quantitative oxygenation with oxygen and CC coupling with carbon monoxide (see graphic). The rhodium hydroxy–alkyl–allyl complex shown is the active intermediate that promotes the elimination of the organic compounds.