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Structure, Bioactivity and Synthesis of Natural Products with Hexahydropyrrolo[2,3‐ b ]indole
Author(s) -
RuizSanchis Pau,
Savina Svetlana A.,
Albericio Fernando,
Álvarez Mercedes
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001451
Subject(s) - indole test , chemistry , stereochemistry , structural motif , combinatorial chemistry , computational biology , biology , biochemistry
Research on natural products containing h exahydro p yrrolo[2,3‐ b ] i ndole (HPI) has dramatically increased during the past few years. Newly discovered natural products with complex structures and important biological activities have recently been isolated and synthesized. This review summarizes the structures, biological activities, and synthetic routes for natural compounds containing HPI, emphasizing the different strategies for assembling this motif. It covers a broad range of molecules, from small alkaloids to complex peptides.