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Integrated Palladium‐Catalyzed Arylation of Heavier Group 14 Hydrides
Author(s) -
Lesbani Aldes,
Kondo Hitoshi,
Yabusaki Yusuke,
Nakai Misaki,
Yamanoi Yoshinori,
Nishihara Hiroshi
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001437
Subject(s) - palladium , aryl , catalysis , chemistry , functional group , silane , group (periodic table) , base (topology) , derivative (finance) , combinatorial chemistry , coupling reaction , medicinal chemistry , reaction conditions , organic chemistry , polymer chemistry , mathematics , alkyl , mathematical analysis , financial economics , economics , polymer
A convenient procedure has been developed for the preparation of Group 14 compounds by integrated palladium‐catalyzed cross‐coupling of aromatic iodides with the corresponding Group 14 hydrides in the presence of a base. The reaction conditions can be applied to the cross‐coupling of tertiary, secondary, and primary Group 14 compounds. In most cases, the desired arylated products were obtained in synthetically useful yields. Even in the case of aryl iodides containing OH, NH 2 , CN, or CO 2 R groups, the reactions proceeded with good to high yields with tolerance of these reactive functional groups. A possible application of this method is the unique synthesis of a fungicidal diarylmethyl(1 H ‐1,2,4‐triazol‐1‐ylmethyl)silane derivative.