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Organocatalytic Direct Vinylogous Michael Addition of α,β‐Unsaturated γ‐Butyrolactam to α,β‐Unsaturated Aldehydes and an Illustration to Scaffold Diversity Synthesis
Author(s) -
Feng Xin,
Cui HaiLei,
Xu Shi,
Wu Li,
Chen YingChun
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001350
Subject(s) - michael reaction , scaffold , diversity (politics) , computer science , chemistry , combinatorial chemistry , organic chemistry , catalysis , programming language , political science , law
Ideal for scaffold diversity synthesis : The first organocatalytic direct vinylogous Michael addition of N ‐Boc α,β‐unsaturated γ‐butyrolactam to α,β‐unsaturated aldehydes has been developed. The products with multiple orthogonal sets of functionalities were transformed into diverse enantioenriched natural‐product‐like or drug‐like molecules with fused bi‐, tri‐, or polycyclic scaffolds (see scheme), which might have potential for biologically related studies.