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Preparation of Highly Hindered Polyenes with tert ‐Butyl Groups in Internal Positions
Author(s) -
Betz Markus,
Hopf Henning,
Ernst Ludger,
Jones Peter G.,
Okamoto Yoshio
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001250
Subject(s) - chemistry , stereochemistry , medicinal chemistry
The conjugated tetraenes 3 and 4 a – c have been prepared and shown to possess an orthogonal structure. This was not only demonstrated by their spectroscopic properties and X‐ray structural analysis of solid representatives (e.g., 4 a – c ) but also by the resolution of these chiral compounds by GC and HPLC chromatography using various chiral selector systems. The chemical behavior of the typical tetraene 4 a has been studied using bromination, hydrogenation, epoxidation, and photo equilibration reactions.