Premium
An Ir–Pt Catalyst for the Multistep Preparation of Functionalized Indoles from the Reaction of Amino Alcohols and Alkynyl Alcohols
Author(s) -
Zanardi Alessandro,
Mata Jose A.,
Peris Eduardo
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001180
Subject(s) - catalysis , chemistry , iridium , alcohol , pyridine , ligand (biochemistry) , ethanol , combinatorial chemistry , medicinal chemistry , alcohol oxidation , organic chemistry , biochemistry , receptor
The 1,2,4‐trimethyltriazolylidene (ditz) ligand allows the preparation of homo‐ and heterodimetallic complexes of Pt 2 and Ir–Pt. These two complexes have been characterized by means of spectroscopic and diffractommetric techniques. The catalytic activity of these complexes, together with that of other Pt‐based compounds, has been explored in the cyclization–addition of alkynyl alcohols and indoles. The Ir–Pt complex [{PtI 2 (py)}(μ‐ditz){IrI 2 (Cp*)}] (py=pyridine; Cp*=pentamethylcyclopentadienyl) allows the combination of an iridium‐mediated oxidative cyclization of 2‐( ortho ‐aminophenyl)ethanol to form indoles, with a further step employing a Pt‐based multistep reaction that functionalizes indoles. Our results show that the Ir–Pt complex is a very active catalyst in this new multistep preparation of functionalized indoles from the reaction of an amino alcohol with alkynyl alcohols.