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Enantioselective Reduction of Ketones and Imines Catalyzed by (CN‐Box)Re V –Oxo Complexes
Author(s) -
Nolin Kristine A.,
Ahn Richard W.,
Kobayashi Yusuke,
KennedySmith Joshua J.,
Toste F. Dean
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001164
Subject(s) - enantioselective synthesis , allylic rearrangement , chemistry , reduction (mathematics) , ketone , catalysis , stereochemistry , organic chemistry , mathematics , geometry
The development and application of chiral, non‐racemic Re V –oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer–Schuster rearrangement/reduction to access enantioenriched allylic alcohols and 2) the enantioselective reduction of imines.