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Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action
Author(s) -
Garcia José,
Barluenga Sofia,
Beebe Kristin,
Neckers Len,
Winssinger Nicolas
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001080
Subject(s) - modularity (biology) , modular design , computer science , retrosynthetic analysis , mechanism (biology) , action (physics) , pharmacophore , information retrieval , chemistry , programming language , stereochemistry , biology , total synthesis , philosophy , epistemology , genetics , physics , quantum mechanics
The concise nature and modularity of the synthesis described for deguelin and tephrosin (retrosynthetic analysis depicted) should facilitate access to labeled analogues to dissect the mechanism of action of this important pharmacophore.