Premium
Kinetic Isotope Effects in Asymmetric Reactions
Author(s) -
Giagou Thomas,
Meyer Matthew P.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001018
Subject(s) - kinetic isotope effect , kinetic energy , steric effects , chemistry , isotope , transition state , chemical physics , catalysis , computational chemistry , physics , stereochemistry , deuterium , organic chemistry , nuclear physics , quantum mechanics
Kinetic isotope effects are exquisitely sensitive probes of transition structure. As such, kinetic isotope effects offer a uniquely useful probe for the symmetry‐breaking process that is inherent to stereoselective reactions. In this Concept article, we explore the role of steric and electronic effects in stereocontrol, and we relate these concepts to recent studies carried out in our laboratory. We also explore the way in which kinetic isotope effects serve as useful points of contact with computational models of transition structures. Finally, we discuss future opportunities for kinetic isotope effects to play a role in asymmetric catalyst development.