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AlCl 3 and BDMAEE: A Pair of Potent Reactive Regulators of Aryl Grignard Reagents and Highly Catalytic Asymmetric Arylation of Aldehydes
Author(s) -
Fan XinYuan,
Yang YongXin,
Zhuo FangFang,
Yu ShengLi,
Li Xiao,
Guo QiPeng,
Du ZhiXue,
Da ChaoShan
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000974
Subject(s) - reagent , catalysis , aryl , yield (engineering) , combinatorial chemistry , chemistry , grignard reagent , function (biology) , organic chemistry , materials science , biology , alkyl , metallurgy , evolutionary biology
Cheap, energy‐saving, and applicable : With the aid of AlCl 3 and BDMAEE [2,2′‐oxybis( N , N ‐dimethylethanamine)], a highly asymmetric catalytic addition of various aryl Grignard reagents to aldehydes was achieved under mild conditions with easily prepared ( S )‐H 8 ‐BINOL and inexpensive commercially available Ti(O i Pr) 4 (see scheme), and the reaction could be easily scaled up with no loss of yield and enantioselectivity.