A Highly Effective Bis(sulfonamide)–Diamine Ligand: A Unique Chiral Skeleton for the Enantioselective Cu‐Catalyzed Henry Reaction | Zendy

Jin Wei | Zendy; Li Xincheng | Zendy; Huang Yongbo | Zendy; Wu Fan | Zendy; Wan Boshun | Zendy

Premium

A Highly Effective Bis(sulfonamide)–Diamine Ligand: A Unique Chiral Skeleton for the Enantioselective Cu‐Catalyzed Henry Reaction

Author(s) -

Jin Wei,

Li Xincheng,

Huang Yongbo,

Wu Fan,

Wan Boshun

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201000964

Subject(s) - sulfonamide , nitromethane , enantioselective synthesis , nitroaldol reaction , diamine , ligand (biochemistry) , catalysis , chemistry , combinatorial chemistry , organic chemistry , biochemistry , receptor

A skeleton in the closet! As a unique chiral skeleton, the newly developed bis(sulfonamide)–diamine, which contains both diamine and bis(sulfonamide) moieties, was a highly effective ligand for the asymmetric Cu(OAc) 2 ‐catalyzed Henry reaction between nitromethane and aldehydes with a low catalyst loading at room temperature (see scheme). Both aliphatic and aromatic aldehydes gave excellent enantioselectivities of up to 99 % ee.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research