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Synthetic Studies Inspired by Vinigrol
Author(s) -
Huters Alexander D.,
Garg Neil K.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000916
Subject(s) - total synthesis , natural product , diterpene , synthetic biology , natural (archaeology) , nanotechnology , chemistry , computer science , biology , computational biology , stereochemistry , materials science , paleontology
Vinigrol, a diterpene natural product, has been a fascinating target for total synthesis for over two decades. This minireview describes recent synthetic studies that have ultimately allowed access to the coveted vinigrol scaffold. Barriault’s synthesis of the vinigrol core is described, in addition to the elegant strategies disclosed by Njarđarson and Hanna. The first total synthesis of vinigrol, reported by Baran in 2009, is also highlighted. This review showcases the fundamental role that natural products play in spawning innovations in synthetic chemistry.