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Photolysis and Thermolysis of Platinum(IV) 2,2′‐Bipyridine Complexes Lead to Identical Platinum(II)–DNA Adducts
Author(s) -
Loup Christophe,
Tesouro Vallina Ana,
Coppel Yannick,
Létinois Ulla,
Nakabayashi Yasuo,
Meunier Bernard,
Lippert Bernhard,
Pratviel Geneviève
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000850
Subject(s) - platinum , adduct , chemistry , thermal decomposition , photodissociation , 2,2' bipyridine , photochemistry , organic chemistry , catalysis , crystal structure
Two Pt IV and two Pt II complexes containing a 2,2′‐bipyridine ligand were treated with a short DNA oligonucleotide under light irradiation at 37 °C or in the dark at 37 and 50 °C. Photolysis and thermolysis of the Pt IV complexes led to spontaneous reduction of the Pt IV to the corresponding Pt II complexes and to binding of Pt II 2,2′‐bipyridine complexes to N7 of guanine. When the reduction product was [Pt(bpy)Cl 2 ], formation of bis‐oligonucleotide adducts was observed, whereas [Pt(bpy)(MeNH 2 )Cl] + gave monoadducts, with chloride ligands substituted in both cases. Neither in the dark nor under light irradiation was the reductive elimination process of these Pt IV complexes accompanied by oxidative DNA damage. This work raises the question of the stability of photoactivatable Pt IV complexes toward moderate heating conditions.