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On the Design of Fluorescent Ratiometric Nanosensors
Author(s) -
Doussineau Tristan,
Schulz Anja,
LaprestaFernandez Alejandro,
Moro Artur,
Körsten Susanne,
Trupp Sabine,
Mohr Gerhard J.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000829
Subject(s) - nanosensor , fluorescence , nanotechnology , materials science , physics , optics
Advances in nanoparticle technology have recently offered new tools to the bioanalytical field of research. In particular, new nanoparticle‐based sensors have appeared able to give quantitative information about different species (ions, metabolites, biomolecules) in biosamples through ratiometric measurements. This article describes the methodologies developed so far in the design of such nanosensors. In particular, the different approaches to immobilize fluorescent chemosensor dyes to nanoparticles are presented. Concept designs of ratiometric nanosensors in terms of composition and architecture are also described and illustrated with examples taken from the literature.