On the NH Effect in Ruthenium‐Catalysed Hydrogenation of Ketones: Rational Design of Phosphine‐Amino‐Alcohol Ligands for Asymmetric Hydrogenation of Ketones | Zendy

Phillips Scott D. | Zendy; Fuentes José A. | Zendy; Clarke Matthew L. | Zendy

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On the NH Effect in Ruthenium‐Catalysed Hydrogenation of Ketones: Rational Design of Phosphine‐Amino‐Alcohol Ligands for Asymmetric Hydrogenation of Ketones

Author(s) -

Phillips Scott D.,

Fuentes José A.,

Clarke Matthew L.

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201000790

Subject(s) - phosphine , ruthenium , amine gas treating , ketone , chemistry , alcohol , noyori asymmetric hydrogenation , asymmetric hydrogenation , catalysis , hydrogen , medicinal chemistry , organic chemistry , enantioselective synthesis

Redesign and reduce : The graphic shows some Ru complexes of tridentate ligands that do not contain NH substituents but can catalyse ketone reduction with zero‐order dependence on ketone. In tridentate systems, a secondary amine, not a primary amine, promotes hydrogen activation. Leading on from these observations, the Ru complex of a phosphine‐amino‐alcohol shown above has been found to be a good hydrogenation catalyst.

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