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On the NH Effect in Ruthenium‐Catalysed Hydrogenation of Ketones: Rational Design of Phosphine‐Amino‐Alcohol Ligands for Asymmetric Hydrogenation of Ketones
Author(s) -
Phillips Scott D.,
Fuentes José A.,
Clarke Matthew L.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000790
Subject(s) - phosphine , ruthenium , amine gas treating , ketone , chemistry , alcohol , noyori asymmetric hydrogenation , asymmetric hydrogenation , catalysis , hydrogen , medicinal chemistry , organic chemistry , enantioselective synthesis
Redesign and reduce : The graphic shows some Ru complexes of tridentate ligands that do not contain NH substituents but can catalyse ketone reduction with zero‐order dependence on ketone. In tridentate systems, a secondary amine, not a primary amine, promotes hydrogen activation. Leading on from these observations, the Ru complex of a phosphine‐amino‐alcohol shown above has been found to be a good hydrogenation catalyst.