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“On‐Water,” Microwave‐Assisted, Pd‐Catalyzed Synthesis of Indoles from Imines and o ‐Difunctionalized Arenes
Author(s) -
Barluenga José,
JiménezAquino Agustín,
Aznar Fernando,
Valdés Carlos
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000753
Subject(s) - catalysis , solvent , microwave , chemistry , reaction conditions , combinatorial chemistry , organic solvent , organic chemistry , polymer chemistry , chemical engineering , computer science , telecommunications , engineering
Regioselectively substituted indoles are prepared by a Pd‐catalyzed CC/CN bond‐forming sequence from imines and o ‐dihaloarenes or o ‐haloarene sulfonates. The heterogeneous reaction as a suspension in water and under microwave heating offers important advantages in comparison with the conventional reaction in an organic solvent, among them, operational simplicity, the employment of KOH solutions instead of alkoxides, and a dramatic reduction of reaction times.