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Exclusive Synthesis of β‐Alkylpyrroles under Indium Catalysis: Carbonyl Compounds as Sources of Alkyl Groups
Author(s) -
Tsuchimoto Teruhisa,
Igarashi Motohiro,
Aoki Kazuki
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000733
Subject(s) - indium , alkyl , nucleophile , mixing (physics) , catalysis , chemistry , carbonyl group , nitrogen , organic chemistry , group (periodic table) , combinatorial chemistry , medicinal chemistry , physics , quantum mechanics
No longer difficult : Just mixing readily available carbonyl compounds, pyrroles, and nucleophiles with an indium catalyst was found to give β‐alkylpyrroles in a regiospecific manner. Removal of benzyl (Bn) and cumyl groups from the nitrogen atoms of the products enables access to nitrogen‐unsubstituted β‐alkylpyrroles (see scheme).