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Syntheses and Antibacterial Properties of iso ‐Platencin, Cl‐ iso ‐Platencin and Cl‐Platencin: Identification of a New Lead Structure
Author(s) -
Tiefenbacher Konrad,
Gollner Andreas,
Mulzer Johann
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000706
Subject(s) - combinatorial chemistry , lead (geology) , identification (biology) , lead compound , antibiotics , chemistry , stereochemistry , antibacterial activity , molecule , structure–activity relationship , computational biology , biology , bacteria , organic chemistry , biochemistry , in vitro , ecology , paleontology , genetics
Platencin is a novel antibiotic which is active against multiresistant pathogens. We describe efficient syntheses of three platencin analogues of varying activities which allow further conclusions about the pharmacophoric part of the molecule. The unnatural antibiotic iso ‐platencin, which is about as active as natural platencin, but much more selective, was identified as a new lead structure.