Curvularides A–E: Antifungal Hybrid Peptide–Polyketides from the Endophytic Fungus  Curvularia geniculata | Zendy

Chomcheon Porntep | Zendy; Wiyakrutta Suthep | Zendy; Aree Thammarat | Zendy; Sriubolmas gluksna | Zendy; Ngamrojanavanich Nattaya | Zendy; Mahidol Chulabhorn | Zendy; Ruchirawat Somsak | Zendy; Kittakoop Prasat | Zendy

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Curvularides A–E: Antifungal Hybrid Peptide–Polyketides from the Endophytic Fungus Curvularia geniculata

Author(s) -

Chomcheon Porntep,

Wiyakrutta Suthep,

Aree Thammarat,

Sriubolmas gluksna,

Ngamrojanavanich Nattaya,

Mahidol Chulabhorn,

Ruchirawat Somsak,

Kittakoop Prasat

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201000652

Subject(s) - fungus , curvularia , antifungal , biology , candida albicans , microbiology and biotechnology , fluconazole , peptide , botany , biochemistry , aspergillus

Five new hybrid peptide–polyketides, curvularides A–E ( 1 – 5 ), were isolated from the endophytic fungus Curvularia geniculata , which was obtained from the limbs of Catunaregam tomentosa . Structure elucidation for curvularides A–E ( 1 – 5 ) was accomplished by analysis of spectroscopic data, as well as by single‐crystal X‐ray crystallography. Curvularide B ( 2 ) exhibited antifungal activity against Candida albicans , and it also showed synergistic activity with a fluconazole drug.

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