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Curvularides A–E: Antifungal Hybrid Peptide–Polyketides from the Endophytic Fungus Curvularia geniculata
Author(s) -
Chomcheon Porntep,
Wiyakrutta Suthep,
Aree Thammarat,
Sriubolmas gluksna,
Ngamrojanavanich Nattaya,
Mahidol Chulabhorn,
Ruchirawat Somsak,
Kittakoop Prasat
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000652
Subject(s) - fungus , curvularia , antifungal , biology , candida albicans , microbiology and biotechnology , fluconazole , peptide , botany , biochemistry , aspergillus
Abstract Five new hybrid peptide–polyketides, curvularides A–E ( 1 – 5 ), were isolated from the endophytic fungus Curvularia geniculata , which was obtained from the limbs of Catunaregam tomentosa . Structure elucidation for curvularides A–E ( 1 – 5 ) was accomplished by analysis of spectroscopic data, as well as by single‐crystal X‐ray crystallography. Curvularide B ( 2 ) exhibited antifungal activity against Candida albicans , and it also showed synergistic activity with a fluconazole drug.