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Cross‐Coupling/Cyclization Reactions of Two Different Allenic Moieties
Author(s) -
Alcaide Benito,
Almendros Pedro,
Martínez del Campo Teresa
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000550
Subject(s) - allene , moiety , chemistry , block (permutation group theory) , intramolecular force , coupling reaction , combinatorial chemistry , coupling (piping) , catalysis , stereochemistry , organic chemistry , materials science , metallurgy , geometry , mathematics
The allene moiety represents an excellent building block for allene cross‐coupling cyclization reactions, affording heterocyclic skeletons in a single step. This strategy is of particular interest when two different allene derivatives are involved in a series of metal‐catalyzed cross‐coupling heterocyclization processes. This Concept article is focused on the Pd‐catalyzed union of two different allenic moieties, with cyclization of at least one of them by intramolecular cyclometalation. These new, versatile, and highly effective transformations are complex multistep processes leading to potential privileged structures that could find wide applications in related medicinal chemistry.