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Monodentate N‐Ligand‐Directed Bifunctional Transition‐Metal Catalysis: Highly Enantioselective Friedel–Crafts Alkylation of Indoles with Nitroalkenes
Author(s) -
Guo Fengfeng,
Lai Guoyin,
Xiong Shunshun,
Wang Sujing,
Wang Zhiyong
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000540
Subject(s) - bifunctional , enantioselective synthesis , alkylation , chemistry , friedel–crafts reaction , catalysis , denticity , ligand (biochemistry) , organic chemistry , schiff base , combinatorial chemistry , transition metal , metal , polymer chemistry , biochemistry , receptor
A role beyond base : A highly efficient, asymmetric Friedel–Crafts alkylation of indoles with nitroalkenes is presented that uses simple nitrogen compounds combined with Schiff base zinc(II) complexes as bifunctional catalysts (see scheme). The nitrogen compounds here play a crucial role as ligands as well as their traditional role as bases.