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A Formal Total Synthesis of Palmerolide A
Author(s) -
Gowrisankar Parthasarathy,
Pujari Sandip A.,
Kaliappan Krishna P.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000428
Subject(s) - total synthesis , construct (python library) , moiety , computer science , aldol reaction , stereochemistry , chemistry , programming language , organic chemistry , catalysis
Under the sea : An efficient formal total synthesis of the marine natural product palmerolide A is reported herein, involving 24 longest linear steps. The key features of our synthesis involve a combination of Sharpless epoxidation and Shimizu reaction to construct the syn aldol moiety, a Julia–Kocienski reaction to construct the diene, and ring‐closing metathesis to form the macrocycle (see scheme; PG=protecting group).
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