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Aryl Phosphoramides: Useful Electrophiles for Suzuki–Miyaura Coupling Catalyzed by a NiCl 2 /dppp System (dppp=1,3‐Bis(diphenylphosphino)propane)
Author(s) -
Zhao YuLong,
Li You,
Li Yu,
Gao LianXun,
Han FuShe
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000420
Subject(s) - aryl , electrophile , catalysis , chemistry , phenol , coupling (piping) , combinatorial chemistry , propane , organic chemistry , computer science , database , engineering , mechanical engineering , alkyl
Suzuki–Miyaura coupling : We disclose a new strategy for phenol activation in the first Suzuki–Miyaura coupling of phenol derivatives activated by forming aryl bis(2‐oxo‐3‐oxazolidinyl)phosphines as a highly efficient and broadly applicable methodology for the diverse synthesis of biaryls and heterobiaryls (see scheme). The use of readily available, stable NiCl 2 /dppp as the catalyst system also provides an important advance.
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