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Sub‐Mol % Catalyst Loading and Ligand‐Acceleration in the Copper‐Catalyzed Coupling of Aryl Iodides and Terminal Alkyenes
Author(s) -
Zuidema Erik,
Bolm Carsten
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000344
Subject(s) - copper , catalysis , aryl , ligand (biochemistry) , terminal (telecommunication) , chemistry , monomer , coupling reaction , polymer chemistry , coupling (piping) , combinatorial chemistry , inorganic chemistry , materials science , organic chemistry , metallurgy , polymer , receptor , telecommunications , biochemistry , alkyl , computer science
Just add ligand! The coupling of aryl iodides and terminal alkynes can be catalyzed with sub‐mol % amounts of a copper complex. Addition of a large excess of diamine ligand converts the inactive polymeric resting state of the catalyst into a highly active monomeric copper species, allowing the title reaction to be performed with such unprecedented low copper loadings.