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Highly Efficient Rh I ‐Catalyzed Asymmetric Hydrogenation of β‐Amino Acrylonitriles
Author(s) -
Ma Miaofeng,
Hou Guohua,
Sun Tian,
Zhang Xiaowei,
Li Wei,
Wang Junru,
Zhang Xumu
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000325
Subject(s) - acetonitriles , catalysis , chemistry , nitrile , combinatorial chemistry , computer science , organic chemistry , acetonitrile
It takes two to TangPhos : β‐Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh–TangPhos (TangPhos=1,1′‐di‐ tert ‐butyl‐(2,2′)‐diphospholane) catalyst system. The products, chiral β‐amino nitriles, are valuable chiral building blocks for many drugs.