Premium
Highly Efficient Rh I ‐Catalyzed Asymmetric Hydrogenation of β‐Amino Acrylonitriles
Author(s) -
Ma Miaofeng,
Hou Guohua,
Sun Tian,
Zhang Xiaowei,
Li Wei,
Wang Junru,
Zhang Xumu
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000325
Subject(s) - acetonitriles , catalysis , chemistry , nitrile , combinatorial chemistry , computer science , organic chemistry , acetonitrile
It takes two to TangPhos : β‐Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh–TangPhos (TangPhos=1,1′‐di‐ tert ‐butyl‐(2,2′)‐diphospholane) catalyst system. The products, chiral β‐amino nitriles, are valuable chiral building blocks for many drugs.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom