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A One‐Pot Palladium‐Catalyzed Allylic Alkylation and Wittig Reaction of Phosphorus Ylides
Author(s) -
Liu WenBo,
He Hu,
Dai LiXin,
You ShuLi
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000316
Subject(s) - wittig reaction , palladium , catalysis , tsuji–trost reaction , chemistry , allylic rearrangement , alkylation , phosphorus , organic chemistry , medicinal chemistry
Put a(n) (y)lid(e) on it! The one‐pot palladium‐catalyzed allylic alkylation and Wittig reaction of phosphorus ylides with various aldehydes and ketenes has been realized, which produce skipped dienes, including trisubstituted alkenes and tetrasubstituted allenes, respectively (see scheme), in moderate to good overall yields.