Highly Recyclable Chemo‐/Biocatalyzed Cascade Reactions with Ionic Liquids: One‐Pot Synthesis of Chiral Biaryl Alcohols | Zendy

Gauchot Vincent | Zendy; Kroutil Wolfgang | Zendy; Schmitzer Andreea R. | Zendy

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Highly Recyclable Chemo‐/Biocatalyzed Cascade Reactions with Ionic Liquids: One‐Pot Synthesis of Chiral Biaryl Alcohols

Author(s) -

Gauchot Vincent,

Kroutil Wolfgang,

Schmitzer Andreea R.

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201000302

Subject(s) - ionic liquid , cascade , chemistry , combinatorial chemistry , aqueous medium , reactivity (psychology) , phase (matter) , organic chemistry , selectivity , aqueous solution , catalysis , chromatography , medicine , alternative medicine , pathology

Mix and match : We report a cascade reaction sequence for the highly enantio‐ and diastereoselective synthesis of biaryl alcohols, employing a Suzuki coupling followed by a biocatalytic reduction in a biphasic system containing ionic liquids (ILs; see figure). We demonstrate the recyclability of the IL phase as well as the aqueous phase up to four cycles with only a negligible deactivation of reactivity and selectivity.

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