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Highly Recyclable Chemo‐/Biocatalyzed Cascade Reactions with Ionic Liquids: One‐Pot Synthesis of Chiral Biaryl Alcohols
Author(s) -
Gauchot Vincent,
Kroutil Wolfgang,
Schmitzer Andreea R.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000302
Subject(s) - ionic liquid , cascade , chemistry , combinatorial chemistry , aqueous medium , reactivity (psychology) , phase (matter) , organic chemistry , selectivity , aqueous solution , catalysis , chromatography , medicine , alternative medicine , pathology
Mix and match : We report a cascade reaction sequence for the highly enantio‐ and diastereoselective synthesis of biaryl alcohols, employing a Suzuki coupling followed by a biocatalytic reduction in a biphasic system containing ionic liquids (ILs; see figure). We demonstrate the recyclability of the IL phase as well as the aqueous phase up to four cycles with only a negligible deactivation of reactivity and selectivity.