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Direct Method for Carbon–Carbon Bond Formation: The Functional Group Tolerant Cobalt‐Catalyzed Alkylation of Aryl Halides
Author(s) -
Amatore Muriel,
Gosmini Corinne
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000178
Subject(s) - halide , alkylation , aryl , alkyl , electrophile , chemistry , catalysis , cobalt , functional group , combinatorial chemistry , medicinal chemistry , organic chemistry , polymer
A new protocol for the direct cobalt‐catalyzed alkylation of aryl halides has been developed that proceeds smoothly in the presence of phosphanes or bipyridines as ligands with a variety of alkyl halides, including challenging alkyl electrophiles bearing β‐hydrogen atoms (see scheme). Sensitive functional groups are tolerated on both coupling partners, thus, significantly extending the general scope of transition‐metal‐catalyzed alkylation of aryl halides.