An Iminocoumarin‐Based Fluorescent Probe for the Selective Detection of Dual‐Specific Protein Tyrosine Phosphatases | Zendy

Kim TaeIl | Zendy; Jeong Myeong Seon | Zendy; Chung Sang J. | Zendy; Kim Youngmi | Zendy

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An Iminocoumarin‐Based Fluorescent Probe for the Selective Detection of Dual‐Specific Protein Tyrosine Phosphatases

Author(s) -

Kim TaeIl,

Jeong Myeong Seon,

Chung Sang J.,

Kim Youngmi

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201000154

Subject(s) - fluorophore , protein tyrosine phosphatase , fluorescence , dual (grammatical number) , tyrosine , phosphatase , intramolecular force , chemistry , biochemistry , dual specificity phosphatase , enzyme , computational biology , computer science , information retrieval , biology , stereochemistry , art , physics , literature , quantum mechanics

Seeing is believing : A fluorescent probe for monitoring the activity of dual‐specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.

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