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An Iminocoumarin‐Based Fluorescent Probe for the Selective Detection of Dual‐Specific Protein Tyrosine Phosphatases
Author(s) -
Kim TaeIl,
Jeong Myeong Seon,
Chung Sang J.,
Kim Youngmi
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000154
Subject(s) - fluorophore , protein tyrosine phosphatase , fluorescence , dual (grammatical number) , tyrosine , phosphatase , intramolecular force , chemistry , biochemistry , dual specificity phosphatase , enzyme , computational biology , computer science , information retrieval , biology , stereochemistry , art , physics , literature , quantum mechanics
Seeing is believing : A fluorescent probe for monitoring the activity of dual‐specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.